Searchable abstracts of presentations at key conferences in endocrinology

ea0014p470 | (1) | ECE2007

Thyrotoxic hypokalemic periodic paralysis in two Caucasian females

Preda Cristina , Leustean Letitia , Vulpoi Carmen , Cristea Cristina , Ungureanu Christina , Zbranca Eusebie

Hypokalemic periodic paralysis is an uncommon complication of thyrotoxicosis especially in Caucasian women. It is most frequent in east asian and Japanese males and is characterized by recurrent episodes of motor weekness of variable intensity associated with hyperthyroidism. It is usually associated with low plasma potassium levels and is often precipitated by physical activity. This condition is a self limiting disorder that is cured by the treatment of the underlying hypert...

ea0014p500 | (1) | ECE2007

Short stature and neurofibromatosis type 1 – issues of diagnosis

Leustean Letitia , Hurjui Cristina , Preda Cristina , Vulpoi Carmen , Moisii Liliana , Zbranca Eusebie

Neurofibromatosis type 1 (NF1) is an inherited disorder characterized by formation of neurofibromas in the skin, brain and other parts of the body, in association with skin pigment changes. It is well known that this condition may be a risk factor for short stature with growth hormone deficiency (GHD) in children, due to suprasellar lesions. We present the case report of a 9-year-old boy admitted in our Service for short stature (-2DS). Physical examination revealed ‘caf&...

ea0056p1010 | Endocrine tumours and neoplasia | ECE2018

Thresholds of basal and calcium stimulated calcitonin for diagnosis of medullary thyroid carcinoma

Baetu Mara , Gheorghiu Cristina , Corneci Cristina , Ioachim Dumitru , Caragheorgheopol Andra , Dobrescu Ruxandra , Badiu Corin

Introduction: The current revised medullary thyroid carcinoma (MTC) guidelines don’t specify reference ranges of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of MTC. These are important for early diagnosis and correct management.Objective: We aimed to set gender specific thresholds for bCT and sCT for MTC diagnosis.Patients and methods: CT samples during calcium-stimulation test (2...

ea0073aep672 | Thyroid | ECE2021

Side-effects of calcitonin stimulation tests with calcium gluconate

Baetu Mara , Olariu Cristina , Nitu Ileana , Moldoveanu Gabriel , Corneci Cristina , Badiu Corin

IntroductionOver time, different substances and protocols have been used and tested for stimulating calcitonin (CT). Some of them proved to be useful in diagnosing medullary thyroid carcinoma (MTC). However, these are associated with side-effects, with various duration, intensity and severity.ObjectiveTo report the side-effects observed during CT stimulation test with calcium (Ca) gluconate.<p class="abst...

ea0063p799 | Thyroid 2 | ECE2019

Cut-off values for basal and calcium stimulated calcitonin for the diagnosis of precocious medullary thyroid carcinoma

Băetu Mara , Olariu Cristina Alexandra , Stancu Cristina , Dobrescu Ruxandra , Moldoveanu Gabriel , Corneci Cristina , Caragheorgheopol Andra , Ioachim Dumitru , Badiu Corin

Introduction: Thresholds of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of medullary thyroid carcinoma (MTC) aren’t specified in current revised MTC guidelines.Objective: We aim to setfemale (F) specific thresholds for bCT and sCT for MTC diagnosis.Methods: CT samples were measured during calcium-stimulation test (25 mg/kg BW adapted to ideal body mass index) before and at 2, 5 and 10 minutes afte...

ea0070ep375 | Reproductive and Developmental Endocrinology | ECE2020

Correlations between clinical suppositions, type of chromosomal anomaly and age for confirmation of diagnosis. A retrospective study of X monosomy

Vlad Gorduza Eusebiu , Martiniuc Violeta , Gramescu Mihaela , Caba Lavinia , Rusus Cristina , Gug Cristina , Florea Ioana , Christina Ungureanu Maria , Carmen Gorduza Nicoleta , Preda Cristina

We made a retrospective study of X monosomy cases identified in our laboratory in the last 10 years. The aim of study was to establish a correlation between different forms of X monosomy, and age for confirmation of cytogenetic diagnosis. Between 2010 and 2019 we confirmed 81 cases of Turner syndrome in our laboratory. We found different forms of X monosomy and the most frequent was X homogenous X monosomy. We found 24 cases (29.62%) of X homogenous monosomy (median age of dia...

ea0081rc6.4 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapor synthesis can target GLUT1 overexpressing tumors: in vitro tests and in vivo preliminary assessment

Barbaro Daniele , Dibari Lorenzo , Gandin Valentina , Marzano Cristina , Evangelisti Claudio

Background: It is well known that one of the basic characteristics of tumor cells is that they are greedy for glucose. Delivering Glucose Coated Superparamagnetic iron oxide nanoparticles (Glc-SPIONs) to tumor cells by i.v. administration could represent “the magic bullet” for detecting and treating cancer,Materials, methods and results: Glc-SPIONs were prepared by a new approach called Metal Vapor Synthesis (MVS) and their structural features ...

ea0081p600 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Esr1 and Esr2 estrogen receptors have different functions in Glut4 expression of 3t3-l1 cells

Pancera Laurindo Caroline , Cristina Rego Gregorio Karen , Fabres Machado Ubiratan

Diabetes mellitus (DM) is an important cause of morbidity and mortality on a global scale. The pathophysiology of DM involves insulin resistance, even in insulin-treated type 1 DM, which in turn is related to the amount of glucose transporter GLUT4 (Slc2a4 gene). Estrogen activity can be mediated by two distinct receptors (ESR1 and ESR2) and may involve genomic and non-genomic mechanisms. Estrogen has been described as involved in glycemic homeostasis, but the related...

ea0081p601 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Isoflavones genistein and daidzein enhance the expression of Slc2a4 mRNA and GLUT4 protein in adipocytes

Rego Gregorio Karen Cristina , Pancera Laurindo Caroline , Fabres Machado Ubiratan

According to the world Health Organization, about 422 million people worldwide have diabetes mellitus (DM), and this number is growing rapidly. DM, mainly type 2, is associated with insulin resistance, which involves reduced expression of glucose transporter GLUT4 (Slc2a4 gene). It is known that estrogen can modulate glycemic homeostasis and seems to involve changes in the Slc2a4/GLUT4 expression. There has been an increased interest in plant-derived phytoest...

ea0081p410 | Pituitary and Neuroendocrinology | ECE2022

Favorable liver safety profile of the selective glucocorticoid receptor modulator relacorilant in healthy and hepatically impaired adults and in patients with cushing syndrome

G. Moraitis Andreas , Custodio Joseph , Cristina Tudor Iulia

Background: Relacorilant is a highly selective glucocorticoid receptor (GR) modulator in development for the treatment of endogenous Cushing syndrome (CS). Unlike the GR antagonist mifepristone, relacorilant lacks affinity for the progesterone and other receptors. In a phase 2 study in patients with CS (Pivonello et al, 2021), relacorilant provided clinically meaningful changes in several cortisol-excess-related comorbidities, including hypertension and hyperglycemia,...